Chromogranin A is an autoantigen in type 1 diabetes
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Citrullinated glucose - regulated protein 78 is an autoantigen in type 1 diabetes . Running title : GRP 78 is an autoantigen in type 1 diabetes
Post-translational modifications of self-proteins play a substantial role in the initiation or propagation of the autoimmune attack in several autoimmune diseases, but their contribution to type 1 diabetes is only recently emerging. In the present study we demonstrate that inflammatory stress, induced by the cytokines IL-1β and IFNγ, leads to citrullination of GRP78 in beta-cells. This is coupl...
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Chromogranin A (ChgA) is an autoantigen for CD4(+) T cells in the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D). The natural ChgA-processed peptide, WE14, is a weak agonist for the prototypical T cell, BDC-2.5, and other ChgA-specific T-cell clones. Mimotope peptides with much higher activity share a C-terminal motif, WXRM(D/E), that is predicted to lie in the p5 to p9 position i...
متن کاملCitrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes.
Posttranslational modifications of self-proteins play a substantial role in the initiation or propagation of the autoimmune attack in several autoimmune diseases, but their contribution to type 1 diabetes is only recently emerging. In the current study, we demonstrate that inflammatory stress, induced by the cytokines interleukin-1β and interferon-γ, leads to citrullination of GRP78 in β-cells....
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2010
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.1844